Breen labs will be the coordinator of the groups that will be studying hemangiosarcoma in Dachshunds, the Van Andel Institute and Dr. Jaime Modiano of the Oncology and Comparative Medicine
The Van Andel Institute is studying only naturally occurring tumors, so we need the assistance of owners with dogs who develop Hemangiosarcoma, Osteosarcoma, Lymphoma, Malignant histiocytosis, Melanoma (oral and digital).
We are requesting fresh (not in formalin) tumor samples when the dog has surgery, a biopsy or is euthanized. We also need 3 mls of blood in an EDTA (purple top) tube. If a tumor sample is not immediately available, (a dog who has had surgery, for example), a blood sample is still useful.
If your dog is scheduled for surgery, please contact
Consent forms and more information for veterinarians can be accessed and downloaded from Van Andelís website, www.vai.org/helpingdogs.
Derivation of Autologous Neural Stem Cells using Induced Pluripotent Stem Cells from Dachshund Dogs
Jose Cibelli, DVM, PhD, Michigan State University D12CA-066
Up to 2 percent of the dogs admitted to the hospital arrive with a spinal cord injury, and 77 percent of these injuries are due to intervertebral disc disease. Long-backed breeds, especially Dachshunds, have the highest incidence of spinal cord injuries. Currently, there is no restorative treatment for spinal cord injuries in dogs. Using funds from Morris Animal Foundation and building on their earlier studies, researchers are exploring the use of induced pluripotent stem cells (iPSCs) as a potential treatment. These stem cells are derived from skin biopsies taken from Dachshunds that undergo emergency surgery. So far, the researchers have obtained skin samples from three Dachshunds. Cells from two of these samples have been successfully reprogrammed into iPSCs and, subsequently, into neural stem cells. This study is demonstrating that derivation of canine iPSCs and canine neural stem cells is feasible. The results may lead to studies into stem cellĖbased therapies for nervous system diseases in dogs.
CANINE GENOME STUDY: Completed
A STUDY TO DETERMINE THE GENETIC RELATIONSHIP AMONGST BREEDS OF DOGS
UNIVERSITY OF MISSOURI:
RESEARCH INTO MOLECULAR CAUSES OF CANINE EPILEPSY
ANIMAL HEALTH TRUST: Completed
RESEARCH INTO PROGRESSIVE RETINAL ATROPHY IN MINIATURE LONGHAIRED
VETERINARY TEACHING COLLEGE AT THE
UNIVERSITY OF TENNESSEE: Completed
acquired retinal degeneration syndrome)
A study of diabetes, hypothyroidism, and hemolytic anemia in all breeds is being conducted by Dr. Wayne Potts and the University of Utah. Cheek-swab DNA samples are being collected. A form must be submitted, including a page that is to be completed by the dog's veterinarian. The form and all other information is available at http://www.malamutehealth.org/grant305.htm
VETERINARY TEACHING COLLEGE AT THE UNIVERSITY OF TENNESSEE: Completed
SARDS (sudden acquired retinal degeneration syndrome)